The present invention provides novel human PDE10 polypeptides,
polynucleotides encoding the polypeptides, expression constructs
comprising the polynucleotides, host cells transformed with the expression
constructs; methods for producing PDE10 polypeptides; antisense
polynucleotides; and antibodies specifically immunoreactive with the PDE10
polypeptides. The invention further provides methods to identify binding
partners of PDE 10, and more particularly, binding partners that modulate
PDE10 enzyme activity.
De onderhavige uitvinding verstrekt nieuwe menselijke PDE10 polypeptiden, polynucleotiden die de polypeptiden, uitdrukkingsconcepten codeert bestaand uit de polynucleotiden, gastheercellen omgezet met de uitdrukkingsconcepten; methodes om polypeptiden te produceren PDE10; antisense polynucleotiden; en antilichamen specifiek immunoreactive met de polypeptiden PDE10. De uitvinding verstrekt verder methodes om het binden partners van PDE te identificeren 10 die, en meer in het bijzonder, partners bindt die PDE10 enzymactiviteit moduleren.
