This procedure consists in the first stage, of the administration of enough
quantity of bisphosphonate preparation during the necessary period of time
to acquire a degree of volumetric mineral density of the cortical tissue
of application, within the normal range (average IDS). Then the
administration of the bisphosphonate preparation is interruption in order
to enable the development of the sectional momentum of inertia. The length
of the second stage can be determined by means of a tomography. That is to
say, that the periods of administration or non-administration of the
mineralizing agent are defined or controlled by precise osteologic
variables and therefore are not fixed. If during the second stage the
cortical mineral density drops by 6-10% of the maximum value previously
obtained, administration of bisphosphonate preparation should be resumed
until the corresponding maximum adjusted value is reached again. The
proposed procedure of a period with bisphosphonate followed by another
period without the bisphosphonate agent improves fracture resistance,
provided that the length of both periods is controlled by defined
osteologic variables.
