A method of monitoring sample crystallization from a solution. The method
includes the collection of multiple Raman spectra from a sample dissolved
in a solvent as a function of time and under conditions promoting
crystallization. Within each of the multiple Raman spectra, a first signal
is identified corresponding to the sample associated with the solvent. A
second signal corresponding to the sample in a microcrystallite state is
also identified. Thereafter, the intensity of the multiple Raman spectra
are measured for an increase relating to formation of the sample in a
microcrystallite state. A method of monitoring sample crystallization from
a solution as a function of turbidity is also disclosed. The method
includes the collection of multiple Raman spectra from a sample dissolved
in a solvent as a function of time under conditions promoting
crystallization. A decrease in intensity is measured across the multiple
Raman spectrum over time, the intensity decrease associated with
macroscopic crystallization opacity. The decrease in intensity is finely
correlated with the onset of macroscopic crystallization of the sample
from the solvent.
