Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat

   
   

The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected cells. Local controlled heating is used to activate the hsp promoter, for example by using focused ultrasound controlled by MRI.

La invención proporciona los métodos para usar calor local para controlar la expresión del gene. Recombinan con un gene terapéutico seleccionado y se expresan al promotor del gene de la proteína del choque del calor (hsp) en células seleccionadas. La calefacción controlada local es utilizada para activar al promotor del hsp, por ejemplo usando el ultrasonido enfocado controlado por MRI.

 
Web www.patentalert.com

< Use of estrogen antagonists and estrogen agonists inhibiting pathological conditions

< Method for modulating calcium ion-release-activated calcium ion channels

> Useful aroyl pyrrole heteroaryl methanones and methanols

> Modulation of beta-catenin/TCF-activated transcription

~ 00168