The invention concerns a method for early detection of a flavivirus-induced
infection, comprising the detection of the flavivirus non-structural
glycoprotein NS1 in a biological sample during the clinical phase of the
infection, by an immunological method using at least two identical or
different antibodies, the first antibody consisting of polyclonal or
monoclonal antibodies pre-selected for their high affinity for said NS1
protein hexameric in shape.