Method of changing conformation of a matrix metalloproteinase

   
   

The present invention provides a matrix metalloproteinase inhibiting compound having structure (VIII) or a salt, an enantiomer, a diastereomer, a racemate, or a tautomer thereof. In other embodiments, the present invention provides a method of changing the conformation of a matrix metalloproteinase, a method of inhibiting a matrix metal metalloproteinase, and a method of treating osteoarthritis. ##STR1##

La presente invenzione fornisce un'inibizione di metalloproteinase della tabella compound avendo struttura (viii) o un sale, un enanziomero, un diastereomer, un racemate, o un tautomer di ciĆ². In altri incorporamenti, la presente invenzione fornisce un metodo di cambiare la conformazione di un metalloproteinase della tabella, un metodo di inibizione del metalloproteinase del metallo della tabella e un metodo di trattare la osteoartrite. ## del ## STR1

 
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