The present invention relates to pharmaceutical compositions and methods to
improve expression of exogenous polypeptides into vertebrate cells in
vivo, utilizing delivery of polynucleotides encoding such polypeptides.
More particularly, the present invention provides the use of salts, in
particular sodium and potassium salts of phosphate, in aqueous solution,
and auxiliary agents, in particular detergents and surfactants, in
pharmaceutical compositions and methods useful for direct
polynucleotide-based polypeptide delivery into the cells of vertebrates.
