Disclosed are nucleic acid molecules encoding polypeptides which are
capable of conferring resistance against, and being triggered by, plant
pathogens such as fungi (e.g. Phytophtora infestans and related
isolates). Preferred nucleic acid molecules encode R1 from Solanum
tuberosum, or a variety of homologs, naturally occurring or derivatives)
thereof. Particular methods of activating resistance by using the R1
resistance gene are disclosed, which in certain cases lead to a
hypersensitive response. Further aspects of the invention include
specific primers, vectors, host cells, polypeptides, antibodies,
aptamers, transgenic plants, methods of producing and employing these,
and methods of influencing the resistance trait in a plant. Furthermore,
screening methods for identifying and obtaining plant protective
compounds are provided.
