The present invention provides isolated polypeptides, prolyl
tripeptidyl-peptidases, and active analogs, active fragments or active
modifications thereof, having amidolytic activity for cleavage of a
peptide bond present in a target peptide having at least 30 amino acids.
Isolated nucleic acid fragments encoding isolated prolyl
tripeptidyl-peptidases are also provided, as are methods of reducing
growth of a bacterium by inhibiting a prolyl tripeptidyl-peptidase.
