Histone deacetylase-8 proteins, nuclei acids, and methods for use

   
   

The present invention is directed to novel nucleic acids that encode novel HDAC proteins, which have an affect on chromating structure and transcription. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods of producing the polypeptides of the present invention. Further provided by the present invention are methods of identifying novel compositions which mediate HDAC8 and the use of such compositions in diagnosis and treatment of disease.

La présente invention est dirigée vers les acides nucléiques de roman qui codent les protéines du roman HDAC, qui ont une affectation sur la structure et la transcription chromating. En outre fournis ci-dessus sont des vecteurs et les cellules hôtes comportant ces ordres d'acide nucléique, molécules chimériques de polypeptide comportant les polypeptides de la présente invention fondue aux ordres hétérologues de polypeptide, les anticorps qui lient aux polypeptides de la présente invention et aux méthodes de produire les polypeptides de la présente invention. Plus loin fournies par la présente invention sont des méthodes d'identifier les compositions en roman qui HDAC8 médiat et l'utilisation de telles compositions dans le diagnostic et traitement de la maladie.

 
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< Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase

< Inhibition of histone deacetylase as a treatment for cardiac hypertrophy

> Method for detecting acetyltransferase and deacetylase activities and method for screening inhibitors or enhancers of these enzymes

> Inhibitors of histone deacetylase

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