Polynucleotide and polypeptide sequences are described. The polypeptide
sequences comprise one or more of: (a) a polypeptide having the deduced
amino acid sequence translated from the polynucleotide sequence in SEQ ID
NO: 1 or SEQ ID NO: 5 and variants, fragments, homologues, analogues and
derivatives thereof; (b) a polypeptide of SEQ ID NO: 2 and variants,
fragments, homologues, analogues and derivatives thereof (c) a polypeptide
encoded by the cDNA of NCIMB 41110 and variants, fragments, homologues,
analogues and derivatives thereof; or (d) a polypeptide which has at least
78% identity to (i) the polypeptide encoded by the polynucleotide of SEQ
ID NO: 1 or SEQ ID NO: 5, (ii) the polypeptide of SEQ ID NO: 2, or (iii)
the polypeptide encoded by the cDNA of NCIMB 41110. Such polypeptide
sequences are, inter alia, useful in the prophylaxis and/or treatment of
sexual dysfunction, in particular male erectile dysfunction (MED) or
female sexual dysfunction (FSD), preferably female sexual arousal disorder
(FSAD).
Polynucleotide e as seqüências do polypeptide são descritos. As seqüências do polypeptide compreendem aquele ou mais de: (a) um polypeptide que tem a seqüência deduzida do amino-ácido traduzida da seqüência do polynucleotide no NO. SEQ do ID: 1 ou NO. SEQ do ID: 5 e variants, fragmentos, homologues, analogues e derivatives disso; (b) um polypeptide do NO. SEQ do ID: 2 e variants, fragmentos, homologues, analogues e derivatives disso (c) um polypeptide codificados pelo DNA de NCIMB 41110 e variants, fragmentos, homologues, analogues e derivatives disso; ou (d) um polypeptide que tivesse ao menos a identidade de 78% (i) ao polypeptide codificou pelo polynucleotide do NO. SEQ do ID: 1 ou NO. SEQ do ID: 5. (ii) o polypeptide do NO. SEQ do ID: 2. ou (iii) o polypeptide codificado pelo DNA de NCIMB 41110. Tais seqüências do polypeptide são, alia, úteis inter na profilaxia e/ou no tratamento do dysfunction sexual, no dysfunction erectile masculino particular (MED) ou no dysfunction sexual fêmea (FSD), disorder sexual preferivelmente fêmea do arousal (FSAD).
