Use of lipid conjugates in the treatment of diseases of the nervous system

   
   

The invention provides a method for treating a subject suffering from a disease of the central nervous system which is associated with an inflammatory response, including, inter alia, multiple sclerosis, Amyotrophic Lateral Sclerosis (ALS), meningitis, Alzheimer's disease, pain, HIV-associated dementia, stroke, traumatic brain injury, encephalomyelitis, chronic inflammatory demyelinating polyneuropathy, cerebral ischemia-induced injury or any combination thereof. This invention further provides for the use of a conjugate, or composition comprising the same, for treating the subject, wherein the conjugate comprises a lipid or phospholipid moiety bonded to a physiologically acceptable monomer, dimer, oligomer, or polymer.

La invención proporciona un método para tratar un tema que sufre de una enfermedad del sistema nervioso central incluyendo el cual se asocia a una respuesta inflamatoria, a inter alia, a esclerosis múltiple, a la esclerosis de lateral de Amyotrophic (ALS), a la meningitis, a la enfermedad de Alzheimer, al dolor, a la demencia VIH-ASOCIADA, al movimiento, a lesión traumática del cerebro, a encephalomyelitis, a polyneuropathy demyelinating inflamatorio crónico, a lesión isquemia-inducida cerebral o a cualquier combinación de eso. Esta invención más futura preve el uso de una conjugación, o de la composición que abarca igual, para tratar el tema, en donde la conjugación abarca un moiety del lípido o del phospholipid enlazado a un monomer, a un dimer, a un oligomer, o a un polímero fisiológico aceptable.

 
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