The invention involves a papilloma pseudo-virus that can induce immune
response after oral intake as well as its preparation. It is characterized
in that HPV or BPV pseudo-virus are made by disrupting HPV-VLP or BPV-VLP,
mixing them with plasmids (plasmids or DNA vaccine), and reassembling them
into the pseudo-viruses (VLPs with plasmids inside). Oral administration
of the pseudo-viruses will result in delivery to mucosal and systemic
lymphoid tissues and induce immune responses for disease prevention and
treatment. The pseudo-virus induces stronger immune response than DNA
vaccines. Additionally, the pseudo-virus can be applied in gene therapy by
bringing the therapeutic genes into lymphoid tissues in the human body.
A invenção envolve um pseudo-vírus do papiloma que possa induzir a resposta imune após a entrada oral as.well.as sua preparação. Caracteriza-se que o pseudo-vírus de HPV ou de BPV está feito por HPV-VLP ou por BPV-VLP disrupting, misturando os com os plasmids (plasmids ou vacina do DNA), e remontando os nos pseudo-vírus (VLPs com plasmids para dentro). A administração oral dos pseudo-vírus resultará na entrega aos tecidos lymphoid mucosal e systemic e induzirá respostas imunes para a prevenção e o tratamento da doença. O pseudo-vírus induz uma resposta imune mais forte do que vacinas do DNA. Adicionalmente, o pseudo-vírus pode ser aplicado na terapia do gene trazendo os genes therapeutic em tecidos lymphoid no corpo humano.
