A gastric reduction system and method provides for transesophageal
formation of a gastric reduction pouch of the stomach. The system
includes an expandable structure which may be placed in a stomach and
expanded to occupy a fractional volume of the stomach. An evacuator is
then fed through the expandable structure and utilized to deflate the
stomach and draw the stomach to and around the expandable structure to
form the gastric reduction pouch. A self-deploying fastener is then
deployed to maintain the gastric reduction pouch.