A piperidin-2-one derivative compound represented by formula (I): 1
wherein all symbols are described in the specification, or a non-toxic
salt thereof.
The compound represented by formula (I) inhibits activation of p38MAP
kinase, and is useful for prevention and/or treatment of various
inflammatory diseases, rheumatoid arthritis, osteoarthritis, arthritis,
osteoporosis, autoimmune diseases, infectious diseases, sepsis, cachexia,
cerebral infarction, Alzheimer's disease, asthma, chronic pulmonary
inflammatory diseases, reperfusion injury, thrombosis,
glomerulonephritis, diabetes, graft versus host rejection, inflammatory
bowel disease, Crohn's disease, ulcerative colitis, multiple sclerosis,
tumor growth and metastasis, multiple myeloma, plasma cell leukemia,
Castleman's disease, atrial myxoma, psoriasis, dermatitis, gout, adult
respiratory distress syndrome (ARDS), arteriosclerosis, post-percutaneous
transluminal coronary angioplasty (PTCA) restenosis or pancreatitis.
Een piperidin-2-één afgeleide samenstelling die door formule (I) wordt vertegenwoordigd: 1 waarin alle symbolen in de specificatie, of een niet-toxisch zout daarvan worden beschreven. De samenstelling die door formule (I) wordt vertegenwoordigd remt activering van kinase p38MAP, en is nuttig voor preventie en/of behandeling van diverse ontstekingsziekten, reumatoïde artritis, osteoartritis, artritis, osteoporose, auto-immune ziekten, besmettelijke ziekten, sepsis, cachexie, herseninfarct, de ziekte van Alzheimer, astma, chronische long ontstekingsziekten, reperfusieverwonding, trombose, glomerulonephritis, diabetes, ent tegenover gastheerverwerping, ontstekingsdarmziekte, Crohn's ziekte, ulcerative colitis, multiple sclerose, de tumorgroei en metastase, veelvoudige myeloma, de leukemie van de plasmacel, de ziekte van Castleman, atrial myxoma, psoriasis, dermatitis, gout, volwassen ademhalingsnoodsyndroom (ARDS), arteriosclerose, post-percutane transluminal
