Methods and kits for diagnosing tumorigenicity and determining resistance to the antineoplastic effects of antiestrogen therapy

   
   

Methods and kits for diagnosing tumorigenicity and for determining whether a cancer patient is resistant to the pharmacological effects of antiestrogen therapy. Increased levels of the PCDGF (GP88) growth factor are indicative of tumorigenicity and resistance to the pharmacological effects of antiestrogen therapy. The methods and kits of the invention are useful for assessing the tumorigencity of a biological sample from a patient and determining whether the patient is a candidate for antiestrogen, including tamoxifen, therapy.

Metodi e corredi per il tumorigenicity di diagnostica e per la determinazione se un paziente del cancro è resistente agli effetti farmacologici della terapia di antiestrogen. I livelli aumentati del fattore di sviluppo di PCDGF (GP88) sono indicativi del tumorigenicity e della resistenza agli effetti farmacologici della terapia di antiestrogen. I metodi ed i corredi dell'invenzione sono utili per valutare il tumorigencity di un campione biologico da un paziente e la determinazione se il paziente è un candidato per il antiestrogen, includente tamoxifen, terapia.

 
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