Disclosed are water soluble compositions of paclitaxel and docetaxel formed
by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic
acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the
compositions for treatment of tumors, auto-immune disorders such as rheumatoid
arthritis. Other embodiments include the coating of implantable stents for prevention
of restenosis.