The invention includes antibiotic pharmaceutical compositions comprising eukaryotic
histone H1 protein and methods of using eukaryotic histone H1 protein to kill or
to inhibit the growth of microorganisms, including, but not limited to, human pathogenic
bacteria. The invention further includes a eukaryotic histone H1-containing animal
feed and methods of improving growth of an animal by supplying the feed to the
animal. The invention still further includes a kit comprising a eukaryotic histone
H1-containing antibiotic pharmaceutical composition and an instructional material
which describes the use of the composition. In addition, the invention includes
a vaccine comprising a eukaryotic histone H1 protein and a method of vaccinating
an animal using the vaccine.
