The invention relates to the use of ubiquicidine or optionally modified peptide
fragments derived therefrom for the preparation of a drug for the treatment, diagnostics
or prophylaxis of infections in humans and animals. A peptide fragment derived
from ubiquicidine comprises for instance a preferably continuous series of at least
3, preferably at least 7-13 amino acids from the amino acid sequence of ubiquicidine;
KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPN ANS (SEQ ID NO: 1). Hybrid
molecules comprise for instance a cationic peptide with an antimicrobial action
and/or a peptide fragment of ubiquicidine and/or a derivative thereof and one or
more effector molecules.
