Indazole compounds that modulate and/or inhibit the activity of certain
protein kinases are described. These compounds and pharmaceutical compositions
containing them are capable of mediating tyrosine kinase signal transduction and
thereby modulate and/or inhibit unwanted cell proliferation. The invention is also
directed to the therapeutic or prophylactic use of pharmaceutical compositions
containing such compounds, and to methods of treating cancer and other disease
states associated with unwanted angiogenesis and/or cellular proliferation, such
as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis,
by administering effective amounts of such compounds.
