The methods and compositions of the invention and the compounds used in
the invention involve a novel immunosuppression mechanism, accelerated
lymphocyte homing immunosuppression (ALH-immunosuppression). For example,
the compound FTY720 specifically directs lymphocytes to the peripheral
lymph nodes, mesenteric lymph nodes, and Peyer's patches. By reversibly
sequestering lymphocytes in these tissues, the compounds can inhibit an
immune response in a mammal. Understanding these mechanisms provides a
novel immunosuppression therapy that can synergistically interact with
other immunosuppressive compounds. Screening methods for identifying
similar ALH-immunosuppression compounds are also described. The invention
allows better treatments and therapies wherever an immunosuppression
regimen is desired.
