A high molecular weight ("HMW") protein of Chlamydia, the amino acid sequence
thereof,
and antibodies that specifically bind the HMW protein are disclosed as well as
the nucleic acid sequence encoding the same. Also disclosed are prophylactic and
therapeutic compositions, comprising the HMW protein, a fragment thereof, or an
antibody that specifically binds the HMW protein or a protein thereof, or the nucleotide
sequence encoding the HMW protein or a fragment thereof, including vaccines.