Disclosed is a method of preparing a rhenium complex by use of a borohydride
exchange resin, including dissolving perrhenic acid in a solution containing ethylenediamine
tetraacetate, mannitol and stannous chloride to obtain a perrhenic acid solution
(step 1), which is then mixed with disulfide in the presence of a borohydride exchange
resin and reacts at room temperature, to obtain a rhenium complex (step 2). The
preparation method of the current invention is characterized in that rhenium is
reduced to have a desired oxidation number through the dissolving of the step 1,
whereby the reaction of the step 2 can occur at room temperature. In addition,
use of the borohydride exchange resin as a reducing agent results in direct formation
of the rhenium complex of sulfide from disulfide, without the need of synthesis
of thiol-protected S-precursor. Therefore, radioactive pharmaceuticals having high
values can be economically and efficiently produced.
