Method of preventing decrease in the activity of protein due to freezing and use of polypeptide in the production of protein activity decrease preventing agent

An objective of the present invention is to provide a means to prevent freeze-induced decrease in protein activity. The present invention relates to a method for preventing freeze-induced decrease in protein activity comprising adding a polypeptide comprising the following amino acid sequence (I) to a protein to be frozen. Further, the present invention relates to use of a polypeptide comprising the following amino acid sequence (I) to produce an agent for preventing freeze-induced decrease in protein activity: (SEQ ID NO: 1) Ser-Ser-Thr-Gly-Ser-X1-Ser-X2-Thr-Asp-X3-X4-X5-X6- X7-X8-Gly-Ser-X9-Thr-Ser-Gly-Gly-Ser-Ser-Thr-Tyr- Gly-Tyr-Ser-Ser-X10-X11-X12-X13-Gly-X14-Val (I).