There is disclosed the use of a compound of formula (I) wherein R1,
R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically
acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament,
for the treatment or prophylaxis of diseases or conditions in which inhibition
of nitric oxide synthase activity is beneficial. Certain novel compounds of formula
(Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates
thereof are disclosed; together with processes for their preparation, compositions
containing them and their use in therapy. The compounds of formulae (I) and (Ia)
are inhibitors of the enzyme nitric oxide synthase and are thereby particularly
useful in the treatment or prophylaxis of inflammatory disease.
##STR1##
