Geometry of a tomosynthesis system including a detector and an x-ray source
is determined using fiducial markers with non-determined positions. The geometry
is determined by arbitrarily identifying at least two markers within an imaged
volume, at different relative distances between the detector and the x-ray source,
without having projections located on a straight line for all different source
positions, and locating the projections of the markers within at least two images
acquired of the imaged volume. The at least two images correspond to different
positions of a focal spot of the x-ray source.