This invention relates to a group of novel sapogenins, their use in anti-cancer
applications, and to a process for their production. More particularly, this invention
pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100
(the dammarance sapogenine structure is specifically clean of any sugar moieties
(glycons) at any position and hydroxyl at C-20) and PAN-20 and PAN-30 (the dammarance
sapogenin structure has sugar moieties but is free of hydroxyl at C-20), obtained
by chemical cleavage of dammarane saponins. The invention also includes a novel
application of the said sapogenins for anti-cancer treatment by using them separately
or together, and/or jointly with other drugs, as well as to the process of producing
these novel sapogenins. Said novel dammarane sapogenins show surprising anti-cancer
effect when applied, particularly against multi-drug resistant cancers.
