The present invention relates to piperidine derivatives of formula (I): 1
wherein
R represents halogen or C.sub.1-4 alkyl;
R.sub.1 represents hydrogen or C.sub.1-4 alkyl;
R.sub.2 represents hydrogen, C.sub.1-4 alkyl;
R.sub.3 represents hydrogen, C.sub.1-4 alkyl;
R.sub.4 represents trifluoromethyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy,
trifluoromethoxy or halogen;
R.sub.5 represents hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl,
C(O)R.sub.6 or S(O).sub.2R.sub.6;
R.sub.6 represents C.sub.1-4 alkyl or C.sub.3-7 cycloalkyl;
m is zero or an integer from 1 to 3;
n is an integer from 1 to 3;
p is an integer from 1 to 2;
X and Y are independently C(O) or CH.sub.2;
provided that
i) X and Y are not both C(O) and
ii) when X and Y are both CH.sub.2 and p is 1, R.sub.5 is not hydrogen,
C.sub.1-4 alkyl or C(O)R.sub.6;
and pharmaceutically acceptable salts and solvates thereof, the process
for their preparation and their use in the treatment of conditions
mediated by tachykinins.
