Provided herein are methods and compositions for modulating the activity
of sirtuin deacetylase protein family members; p53 activity; apoptosis;
lifespan and sensitivity to stress of cells and organisms. Exemplary
methods comprise contacting a cell with an activating compound, such as a
flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or
anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g.,
sphingosine.
