A method, system and computer program product is provided for optimizing
pre-saturation in Magnetic Resonance Imaging. The optimization is done by
setting a correct transmitter frequency of RF pre-pulses for all scan
slices. A B.sub.0 magnetic field map for each scan slice of a scan volume
is obtained from the B.sub.0 magnetic field distribution in the scan
volume. The B.sub.0 magnetic field maps are used to calculate the median
value of the B.sub.0 magnetic field over each scan slice. A first
frequency of RF pre-pulses is obtained by a standard procedure. A second
frequency of RF pre-pulses is then calculated for each scan slice by
adding the median value of the B.sub.0 magnetic field over the scan slice
to the first frequency of RF pre-pulses. Thereafter RF pre-pulses at the
second frequency is applied to the scan slice.