Novel quaternary ammonium compounds of the formula
##STR1##
and any stereoisomers thereof, wherein R1, R2 and R3
independently represent C1-C6 alkyl, optionally substituted
with phenyl or hydroxyl, or both, and wherein any two of R1, R2
and R3 may form a ring together with the quaternary ammonium nitrogen;
R4 represents H, CH3, or COR4-1,
wherein R4-1 represents (C1-C4 alkyl),
(C1-C4 alkoxy), or NR4-2R4-3,
wherein R4-2 and R4-3 independently represent H or
(C1-C4 alkyl); R5, R6 and R7
independently represent H, OCH3, OH, CONH2,
SO2NH2, F, Cl, Br, I,
CF3, or (C1-C4 alkyl), optionally
substituted with one or two OH, (C1-C4 alkoxy),
COOH, or COO(C1-C3 alkyl);
and X- represents an anion of a pharmaceutically acceptable acid, the
compounds for use as medicaments, use of the compounds for the manufacture of specific
medicaments, and pharmaceutical compositions comprising the compounds. The present
invention also concerns a method of treatment involving administration of the compounds.
