A liquid, propellant-free pharmaceutical preparation comprising:
- (a) a first active substance comprising a tiotropium salt, in a concentration
based on tiotropium of between 0.0005% and 5% by weight;
- (b) a second active substance selected from the group consisting of:
an antiallergic, antihistamine, steroid, and leukotriene antagonist;
- (c) a solvent selected from water or a water/ethanol mixture; and
- (d) a pharmacologically acceptable preservative,
- wherein the pH of the preparation is adjusted to between 2.0 and 4.5
with an acid and the tiotropium salt is dissolved in the solvent,
- optionally including a pharmacologically acceptable complexing agent,
stabilizer, a pharmacologically acceptable cosolvent, or other pharmacologically
acceptable adjuvants and additives; a method for administering a pharmaceutical
preparation by nebulizing the pharmaceutical preparation in an inhaler, and a method
of treating asthma or COPD in a patient using the pharmaceutical preparation.
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