The present invention provides pharmaceutical compositions, methods, combinations,
and kits for treating a disorder related to elevated serum cholesterol concentration,
for example, hypercholesterolemia, atherosclerosis, elevated LDL plasma levels,
low HDL plasma levels, hypertriglyceridemia, hyperlipidemia, hypertension, cholesterol
gallstones, and lipid storage diseases. The compositions, methods, combinations,
and kits of the present invention are pharmaceutical compositions comprising atherapeutically
effective amount of a lipid regulating agent, such as a HMG-CoA reductase inhibitor,
and compound that inhibits cholesterol synthesis at a point between the formation
of acetate and mevalonate. A typical pharmaceutical composition of the invention
contains and effective amount of atorvastatin and an effective amount of policosanol.
