A method for obtaining perfusion data includes providing an object of interest,
estimating a first quantity of contrast agent utilized by a mono-energy computed
tomography (CT) imaging system to image the object of interest, introducing a second
quantity of contrast agent into the object of interest, the second quantity of
contrast agent less than the first quantity of contrast agent, and scanning the
object of interest using a multi-energy Computed Tomography (MECT) system to acquire data.