The present invention refers to an RNA molecule with catalytic activity comprising
at least one modified nucleoside, wherein the hydroxy group at the 2-position
of the ribose sugar is replaced by a modifier group, selected from halo, sulfhydryl,
azido, amino, monosubstituted amino and disubstituted amino groups, a process for
the preparation of modified RNA molecules and the use of modified RNA molecules
as therapeutic agents and biocatalysts.
