A brain-protective agent containing an NF-B decoy. In brain diseases,
the
brain can be particularly effectively protected against brain disorders (for example,
cerebral vasospasm following a subrachnoidal hemorrhage and apoptosis of the nerve
cells following a cerebrovasucular accident or serious head injury) caused by the
undesired activation of cytokines or cell adhesion factors which are regulated
by NF-B by administering the brain-protective agent containing an NF-B
decoy, i.e., acompound antadonistic specifically to a nucleic acid to which NF-B binds.