This invention relates to compounds of Formula I, 1
a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a
prodrug thereof, or a pharmaceutically acceptable salt of a prodrug
thereof. The compounds interact with CRF, receptors, including human CRF,
receptors. This invention also relates to methods of using the compounds
of the invention to treat a disorder or condition, the treatment of which
can be effected or facilitated by antagonizing a CRF receptor, such as
CNS disorders or diseases, particularly anxiety-related disorders such as
anxiety, and mood disorders such as major depression.
