A pharmaceutical formulation comprising (i) one or more particulate medicaments,
and (ii) 1,1,1,2-tetrafuoroethane as propellant, which formulation contains less
than 0.0001% w/w surfactant based upon the weight of medicament, particulate medicament
being present in an amount from 00005 to 5% w/w relative to the total weight of
the formulation and having a particle size of less than 100 microns, with the proviso
that the medicament is other than salmeterol, salbutamol, fluticasone propionate,
beclomethasone dipropionate or a physiologically acceptable salt or solvate thereof
and with the proviso that when the formulation consists of betamethasone, ergotamine
tartrate or sodium cromoglycate and 1,1,1,2-tetrafluoroethane the weight to weight
ratio of medicament to propellant is other than 69:7900 or 0.866% w/w.
