Blood glucose concentrations are measured by non-invasive methods and apparatus
using visual pigment bleaching in conjunction with psychophysical methodologies.
Bleaching light of selected wavelengths is projected through the pupil of the eye
of an observer onto the fundus to bleach visual pigments in the eye. The observer's
psychophysical response to a visual stimulus is then measured to obtain information
regarding the rate of regeneration of the visual pigments. From the rate of pigment
regeneration, blood glucose concentrations are measured accurately. The psychophysical
methodologies that may be used with the invention include visual acuity tests and
color-matching tests.