Compositions of substantially homogeneous type II-like collagen from
invertebrates belonging to the class Scyphozoa, phylum Coelenterata, i.e., jellyfish,
particularly Stomolophus meleagris, and methods for its extraction are provided.
Methods for the treatment of arthritis, in particular rheumatoid arthritis, by
administering an effective amount of the collagen-containing compositions of the
invention so as to induce immune tolerance, are also provided.