Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands
   
   

Compounds provided herein are novel substituted tetrahydropurinones of Formula (I): ##STR1##

wherein R3 is aryl substituted with 0-5 XAr or heteroaryl substituted with 0-4 XhAr. Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of various neurologically-related disorders such as affective disorder, anxiety and depression.

 
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