The present invention provides compositions and methods for the treatment of
HIV infection. In particular, the present invention provides non-nucleoside inhibitors
of reverse transcriptase (RT), as well as methods to treat HIV infection using
these non-nucleoside inhibitors of RT. In preferred embodiments, the present invention
provides a novel class of substituted benzimidazoles, effective in the inhibition
of human immunodeficiency virus (HIV) RT.