The present invention provides new chemically modified 4-dedimethylaminotetracycline
compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7,
8, and/or 9 positions and methods for preparing such compounds. Other tetracycline
compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group,
NH-Alkyl, or NNH-Alkyl group substituted at the C4 position as well as
C2 Mannich derivatives. The present invention also provides a method of treating
a mammal suffering from conditions or diseases by administering to the mammal an
effective amount of the new chemically modified tetracycline compounds.
