A pharmaceutical composition comprising two components:
(a) one component comprising a granulation of atorvastatin or
pharmaceutically acceptable salts thereof and a carrier including an
alkalizing agent that forms a pH greater than 5; and
(b) a second component comprising amlodipine or pharmaceutically
acceptable salts thereof and a carrier excluding an alkalizing agent that
forms a pH greater than 5, wherein the two components are combined to
form a final composition for a solid dosage form is described as well as
methods to prepare the compositions, kits for containing such
compositions, and a method of treating angina pectoris, atherosclerosis,
combined hypertension and hyperlipidemia and/or hypercholesterolemia, and
symptoms of cardiac risk using a therapeutically effective amount of the
pharmaceutical composition.
