An in-vitro model apparatus of a human spine and methods for detecting and
analyzing substance distribution patterns therein. In one embodiment, the
model apparatus includes a column body defining a passageway that
substantially mimics the size, shape, and structure of an adult human
spinal canal. Also included is a cord structure that may be located and
anchored within the passageway. The cord structure substantially mimics
the size, shape, and structure of an adult human spinal cord. For
example, the cord structure may include connecting elements that resemble
nerve roots, dentate ligaments, and the septum posticum of a human spine.
The passageway of the model apparatus may be filled with a first fluid
that simulates cerebro-spinal fluid (CSF), and a second fluid containing
a drug (or simulated drug) may be introduced into the passageway, after
which the drug's distribution within the passageway may be analyzed.
