A cephem compound or pharmaceutically acceptable salt thereof represented by
the
formula I:
##STR1##
wherein R1 and R2 may be the same or different and
each represent hydrogen atom, nitro or cyano; R3 represents C1-C6
alkyl which may be substituted with carboxyl; R4 represents hydrogen
atom or amino; X represents S or SO, there being
no case where both of R1 and R2 are simultaneously hydrogen atom.