The invention relates to compositions and methods for treating a patient having
a tumor in order to reduce tumor size, comprising administering to the patient
a replication-competent Paramyxoviridae virus comprising two or more of a) a nucleic
acid sequence encoding a heterologous polypeptide, wherein upon administration
the heterologous polypeptide is detectable in a biological fluid of the patient,
and detection of the heterologous polypeptide is indicative of Paramyxoviridae
virus growth in the patient and reduction in tumor size; b) a recombinant F protein,
H protein, or M protein of Paramyxoviridae virus that increases fusogenicity of
virus with cells; c) a nucleic acid sequence encoding a cytokine; and d) a Paramyxoviridae
virus that is specific for cells of the tumor.
