The present invention relates to a chimeric receptor capable of signaling
both a primary and a co-stimulatory pathway, thus allowing activation of
the co-stimulatory pathway without binding to the natural ligand. The
cytoplasmic domain of the receptor contains a portion of the 4-1BB
signaling domain. Embodiments of the invention relate to polynucleotides
that encode the receptor, vectors and host cells encoding a chimeric
receptor, particularly including T cells and natural killer (NK) cells
and methods of use. Also included is a method for obtaining an enriched
population of NK cells from a mixed population of NK cells and T cells.
