The invention relates to a multiparticulate drug form suitable for uniform release
of an active pharmaceutical ingredient in the small intestine and in the large
intestine, comprising at least two forms of pellets A and B which comprise an active
pharmaceutical ingredient in the core and have different polymer coatings which
determine the release of the active ingredient at different pH values, characterized
in that pellet form A is provided with an inner polymer coating which enables continuous
release of active ingredient, and has an outer enteric coating which rapidly dissolves
above about pH 5.5, and pellet form B is provided with a polymer coating which,
in the USP release test, releases less than 20% of the active ingredient at pH
6.8 in 6 hours and releases more than 50% of the active ingredient at pH 7.2 in
6 hours. The invention additionally relates to a process for producing the multiparticulate
drug form and to the use of pellet forms A and B for producing the drug form.
