Premature vascular senescence is reversed or prevented in tissue or cells
by contacting the tissue or cells with a peroxynitrite scavenger or
peroxynitrite formation inhibitor that does not diminish nitric oxide
synthesis. This finds application in treatment of patients with a
disorder associated with elevated levels of advanced glycation end
products in blood or tissue, e.g., patients with end stage renal disease
or poorly controlled diabetes, and in contacting vascular tissue or cells
ex vivo to prevent occurrence of premature senescence.
